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KMID : 0366220070420020176
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Korean Journal of Hematology
2007 Volume.42 No. 2 p.176 ~ p.179
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Azacitidine-induced Hepatotoxicity in a Patient with Myelodysplastic Syndrome
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Kim Jin-Soo
Lim Joo-Han
Yi Hyeon-Gyu
Park Hyun-Min
Lee Moon-Hee
Kim Chul-Soo
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Abstract
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Hematopoietic stem cell transplantation remains the only curative option for myelodysplastic syndrome (MDS), but the prevalence of the disease in elderly people limits broad application of the procedure, particularly in lower risk group. Azacitidine has been recently approved by the U.S. Food and Drug Administration for MDS regardless of subtype on French-American-British classification. Adverse effects of azacitidine include gastrointestinal, hematological and infusion-related reactions. Azacitidine induced hepatotoxicity has been reported mainly in patients with previous hepatobiliary disease, e.g., extensive tumor infiltration in liver, liver cirrhosis and cholelithiasis. We report here a case of azacitidine-induced hepatitis under no predisposition to hepatobiliary disease. (Korean J Hematol 2007;42:176-179.)
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KEYWORD
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Myelodysplastic syndrome, Azacitidine, Adverse effects, Hepatitis, Toxic, Hepatitis, Drug-induced
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